Only you can decide your priorities...

Ask any gardener and they will tell you that most flowering plants need to be pruned.  The thing about pruning, is that you often end up cutting off good stuff:  roses that are blooming, grape clusters, budding peppers...

In deciding about opportunities, the reality is that many times you will be saying no to 'good stuff.'  Turning down a speaking engagement because it isn't strategic for you, deciding not to read a certain book or take a class because it is simply one more thing in your schedule.

It is hard to say no to 'good stuff.'  But it is the only way you can get to 'better stuff.'